US 2011/0236389 A1 · Human Angiostatin Interacting and Tumor Metastasis Involving Protein Variants and Uses Thereof

Abstract

The invention provides human angiostatin interacting and tumor metastasis involving protein (HAI-TMIP) isoforms, namely HAI-TMIP variants 1 to 7, and human protein complexes comprising HAI-TMIP variant 1, 2, 3, 4, 5, 6 or 7. The invention also provides antibodies that immunospecifically bind to HAI-TMIP variant 1, 2, 3, 4, 5, 6 or 7 or a complex comprising such a variant, and uses of such antibodies. The present invention provides peptides which may be used as immunogens to distinguish between the HAI-TMIP variants. The invention further provides compounds that modulate the expression and/or activity of HAI-TMIP variant 1, 2, 3, 4, 5, 6 or 7, or a complex comprising such a variant, and uses of such compounds in the prevention, treatment and/or management of various disorders, in particular, cancer.

Claims28

Dependent claims

An isolated nucleic acid molecule comprising:

a) the nucleotide sequence of SEQ ID NO:
1, 2, 3, 4, 5, 6, 7, 37, 38, 39, 40 or 41;
b) the nucleotide sequence which encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:8 or 9;
c) a nucleotide sequence comprising nucleic acid residues 123 to 309 of SEQ ID NO:4;
d) a nucleotide sequence comprising nucleic acid residues 468 to 557 of SEQ ID NO:5;
e) a nucleotide sequence which hybridizes to the complement of the nucleotide sequence of SEQ ID NO:
1, 2, 3, 4, 5, 6 or 7;
f) a nucleotide sequence which hybridizes to the complement of a nucleotide sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO:8 or 9;
or
g) a nucleotide sequence that is at least 95% identical to the nucleotide sequence of SEQ ID NO:
1, 2, 3, 4, 5, 6 or 7.

8 more elements

Dependencies are inferred from the claim text.

Human Angiostatin Interacting and Tumor Metastasis Involving Protein Variants and Uses Thereof

Life of this patent

Human Angiostatin Interacting and Tumor Metastasis Involving Protein Variants and Uses Thereof

Life of this patent

Abstract

Claims28