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US 2011/0236376 A1Published application
Non-neutralizing immunity to influenza to prevent secondary bacterial pneumonia
OwnerStephen T. Smiley, Laura Haynes +1inventors
InventorsSTEPHEN T. SMILEY, LAURA HAYNES, TROY DOUGLAS RANDALL
Life of this patent
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Abstract
The prevention and treatment of secondary bacterial pneumonia is described, by using passive immunization with antibodies (e.g. polyclonal, monoclonal, etc.) to one or more conserved influenza proteins. Both antibodies and fragments thereof are contemplated, raised against conserved proteins such as nucleoproteins.
Claims40
A method for treating a person at risk of secondary bacterial pneumonia comprising:
- a) providing:
- i) a subject exhibiting symptoms of a viral infection who is at risk for secondary bacterial pneumonia, and
- ii) a composition comprising antibody or fragment thereof reactive with a viral nucleoprotein;
- and
- b) administering said composition to said subject under conditions such that the risk of secondary bacterial pneumonia is reduced.
2 more elements
A method for treating a subject at risk of secondary bacterial pneumonia comprising:
- a) providing:
- i) a subject exhibiting symptoms of an Influenza A viral infection who is at risk for secondary bacterial pneumonia, and
- ii) a composition comprising antibody or a fragment thereof reactive with Influenza A viral protein selected from the group consisting of PB1, PB2, PA, NP, NS1, NS2, Ml, M2 and PB1-F2;
- and
- b) administering said composition to said subject under conditions such that the risk of secondary bacterial pneumonia is reduced.
2 more elements
A method for protecting against a secondary bacterial pneumonia infection comprising:
- a) providing:
- i) a subject at risk for an Influenza A viral infection and secondary bacterial pneumonia, and
- ii) a composition comprising antibody or fragment thereof reactive with Influenza A viral protein selected from the group consisting of PB1, PB2, PA, NP, NS1, NS2, Ml, M2 and PB1-F2;
- and
- b) administering said composition to said subject prior to any symptoms of infection.
2 more elements
Dependencies are inferred from the claim text.