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US 2011/0236372 A1Published application
Display Library for Antibody Selection
AssigneePhilochem AG
InventorAlessandra Villa
Life of this patent
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Abstract
Synthetic antibody display library containing human germline antibody molecules with variation in VH CDR3 and VL CDR3 and at position 52 of VH CDR2, for screening and selection of antibody molecules specific for antigens of interest.
Claims24
A library of antibody molecules, wherein each antibody molecule comprises a VH domain consisting of VH CDR1, CDR2 and CDR3 and framework regions, wherein
- the VH domain amino acid sequence corresponds to a human germline antibody heavy chain sequence in which the residue at position 52 in VH CDR2 is mutated from germline and wherein residues in VH CDR3 are variably mutated.
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10-21. (canceled)
29-36. (canceled)
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Dependencies are inferred from the claim text.