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AssigneeDuke University
InventorsJames O. McNamara, Xiao-Ping He, Yangzhong Huang, Bin Gu, Enhui Pan
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The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides, that when administered disrupt TrkB-mediated activation of PLCγ1 phosphorylation. The invention further provides method of treatment comprising administering inhibitors of TrkB-mediated activation of PLCγ1 phosphorylation alone or in combination with other pharmaceutical compositions to prevent or ameliorate nervous system disorders such as epilepsy, stroke, anxiety, migraine, and pain.
A method of treating a disorder of the nervous system in a subject comprising administering to said subject a therapeutically effective amount of an interfering molecule, wherein said interfering molecule inhibits TrkB-mediated activation of PLCγ1.
A method of ameliorating a disorder of the nervous system in a subject comprising administering to said subject a therapeutically effective amount of an interfering molecule, wherein said interfering molecule inhibits TrkB-mediated activation of PLCγ1.
A method for preventing onset or limiting the progression of a disorder of the nervous system in a subject comprising administering to said subject a therapeutically effective amount of an interfering molecule inhibits TrkB-mediated activation of PLCγ1.
An isolated phosphopeptide comprising the amino acid sequence YGRKKRRQRRRLQNLAKASPVYLDI (SEQ ID NO:
Dependencies are inferred from the claim text.