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US 2011/0236344 A1Published application
Synthetic mimics of mammalian cell surface receptors: method and compositions
AssigneeThe Penn State Research Foundation
InventorBlake R. Peterson
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Abstract
The present invention relates to new synthetic receptors. More particularly, the present invention relates to the use of the synthetic receptors for delivering a protein, peptide, drug, prodrug, lipid, nucleic acid, carbohydrate or small molecule into a target cell via receptor-mediated endocytosis. According to the invention, novel synthetic mimics of cell surface receptors have been designed and methods for use of the same are disclosed.
Claims8
A method of producing a therapeutic effect by delivering a synthetic cell receptor into a cell comprising:
- contacting said cell with a synthetic cell receptor that inserts into a cell plasma membrane on a cell surface wherein said receptor comprises:
- a target-binding motif, wherein said target-binding motif binds or is covalently linked to a target;
- a linker region linking a membrane-binding element with the target-binding motif,
- wherein said membrane-binding element anchors said receptor into a cell plasma membrane and is a derivative of 3β-cholesterylamine or 3β-dihydrocholesterylamine;
- triggering receptor-mediated endocytosis of said receptor;
- delivery of said receptor to said cell by an endosome;
- and
- disrupting said endosome by an endosome disrupter to release said target and produce said therapeutic effect.
5 more elements
Dependencies are inferred from the claim text.