Animal model of an ejaculation-like reflex
AssigneeAstellas Pharma Inc.
InventorsMasayuki TANAHASHI, Karl Bruce THOR, Venkateswarlu KARICHETI
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Abstract
An animal model of an ejaculation-like reflex, wherein the ejaculation-like reflex is induced by continuous infusion of saline through a catheter extending into the proximal urethra of a non-human male animal, and wherein the urethra of the animal is occluded by extending and bending the penis at the base; and a method of screening a test substance for effectiveness in prevention or treatment of male ejaculatory dysfunction using the animal model.
Claims12
A non-human male animal model of an ejaculation-like reflex, wherein the penis of said animal is extended and bent at the base, and wherein said animal is continuously infused saline through a catheter extending into the proximal urethra.
A non-human male animal model of an ejaculation-like reflex produced by continuous infusion of saline through a catheter extending into the proximal urethra of the animal and by occlusion of the infused urethra by extending and bending the penis at the base.
A method of producing a non-human male animal model of an ejaculation-like reflex, comprising:
- (a) inserting into a non-human male animal a catheter extending into the proximal urethra;
- (b) continuously infusing saline into the animal through the catheter, and
- (c) inducing urethral occlusion in the animal by extending and bending the penis at the base.
A method of screening a test substance for effectiveness in prevention or treatment of human male premature ejaculation or delayed ejaculation, comprising:
- (a) inserting into a non-human male animal a catheter extending into the proximal urethra;
- (b) continuously infusing saline into the animal through the catheter during a test;
- (c) administering a test substance to the animal;
- (d) inducing urethral occlusion in the animal by extending and bending the penis at the base;
- (e) measuring at least one of (i) latency of an ejaculation-like reflex and (ii) a threshold of urethral pressure for the ejaculation-like reflex;
- and
- (f) selecting a test substance that prolongs or shortens latency of the ejaculation-like reflex, or increases or decreases threshold of urethral pressure causing the ejaculation-like reflex based on the result obtained in (e).
Dependencies are inferred from the claim text.