Nucleoside analogues useful as positron emission tomography (pet) imaging agents
AssigneeImperial Innovations Limited
InventorsEric Ofori Aboagye, Graham Smith
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Abstract
The invention provides compounds that comprise a 4′-thio nucleoside that is a derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a positron or single photon emitting radioisotope or corresponding non-radioactive isotope attached via a triazole link to the N-3 position. Methods for preparing such compounds and uses of the compounds in medicine are also provided.
Claims30
A 4′-thio nucleoside that is a derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a positron or single photon emitting radioisotope or corresponding non-radioactive isotope attached via a triazole link to the N-3 position.
A derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a terminal alkyne attached via the N-3 position.
A derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a terminal azide attached via the N-3 position.
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A kit of parts comprising a derivative of 4′-thiothymidine or 4′-thio-2′-deoxyuridine comprising a terminal alkyne or azide attached via the N-3 position and a radiolabelled (or corresponding non-radiolabelled) compound comprising an azide group or terminal alkyne group.
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Dependencies are inferred from the claim text.