Aryl Bidentate Isonitriles and Their Uses
AssigneeThe General Hospital Corporation
InventorsDavid R. Elmaleh, Timothy M. Shoup, Alan J. Fischman, Bhaskar C. Das
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Abstract
The present invention relates generally to chelation compounds, radionuclide metal chelate compounds, i.e., complexes, and radiolabeled targeting moieties, i.e., conjugates, formed therefrom, and methods of using these compounds, complexes and conjugates for diagnostic and therapeutic purposes. This invention is more particularly related to aryl bidentate isonitrile metal complexes generated by a chemical interaction of a metal salt oxide or weak complex of the metal with aryl isonitrile bidentate ligands.
Claims12
An aryl bidentate isonitrile ligand having the structure:
- wherein X and X1 are independently a hydrogen or a substituent on the aryl group and R and R1 are independently a straight or branched alkyl group.
A method for imaging body tissues comprising administering to a subject a radiopharmaceutical composition comprising a coordination complex of an aryl bidentate isonitrile ligand and a radionuclide, and detecting the localization of such complex in the body tissues by a gamma camera.
A method for delivering a therapeutic composition to a subject, comprising administering to a subject a therapeutic composition comprising a coordination complex of an aryl bidentate isonitrile ligand and a therapeutic.
Dependencies are inferred from the claim text.