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US 2011/0236305 A1Published application
Methods for protecting and regenerating bone marrow using cxcr3 agonists and antagonists
AssigneeGeneral Regeneratives Holdings, Inc.
InventorsWei Han, Huili Lu, Di Xiang
Life of this patent
Estimating the term…
Abstract
CXCR3 agonists, including natural CXCR3 ligands, promote bone marrow regeneration, increase peripheral white blood cells, and increase survival if administered prior to treatment of a subject with chemotherapy or radiotherapy. Similar effects are obtained by administering an CXCR3 antagonists following chemotherapy radiotherapy. Compositions and methods are presented for the treatment of cancer and bone marrow diseases.
Claims15
A method for myeloprotection comprising:
- administering an effective amount of a CXCR3 agonist to a subject prior to administering chemotherapy or radiotherapy to the subject, wherein following chemotherapy or radiotherapy the bone marrow cell density or the level of peripheral white blood cells of the subject is increased compared to a control subject not receiving the CXCR3 agonist.
Dependencies are inferred from the claim text.