Atlas-Assisted Synthetic Computed Tomography Using Deformable Image Registration
AssigneeEmory University
InventorsEduard Schreibmann, Tim Fox
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Abstract
Disclosed are systems for and methods of creating a synthetic image by registering a reference or atlas image to a clinical image using both rigid and deformable image registration algorithms. In some embodiments, a synthetic computed tomography (CT) image may be created by registering an atlas CT image to a clinical image such as an MR scan. Rigid registration in some embodiments may be followed by a smoothing B-spline transform algorithm with a mutual information similarity metric and an optimizer; followed then by an image signal intensity algorithm with displacement vectors at each voxel and diffeomorphic transformations.
Claims25
A system for creating a synthetic computed-tomography (CT) image volume, comprising:
- a rigid registration algorithm configured to register a reference CT image volume to a first clinical image volume and thereby produce a first registration;
- a smoothing function configured to further refine said first registration and thereby produce a smoothed registration;
- and
- a voxelwise intensity algorithm configured to further refine said smoothed registration and thereby produce a synthetic CT image volume having characteristics correlated to those of said first clinical image volume.
A method of creating a synthetic computed-tomography (CT) image volume, the method comprising:
- obtaining a first clinical image volume;
- retrieving a reference CT image volume;
- applying a rigid registration algorithm to register said reference CT image volume to said first clinical image volume and thereby produce a first registration;
- applying a smoothing function to said first registration and thereby produce a smoothed registration;
- and
- applying a voxelwise intensity algorithm to said smoothed registration and thereby produce a synthetic CT image volume having characteristics correlated to those of said first clinical image volume.
A non-transitory computer-readable medium, the contents of which cause a computing system to perform a method of creating a synthetic computed-tomography (CT) image volume, the method comprising:
- obtaining a first clinical image volume;
- retrieving a reference CT image volume;
- applying a rigid registration algorithm to register said reference CT image volume to said first clinical image volume and thereby produce a first registration;
- applying a smoothing function to said first registration and thereby produce a smoothed registration;
- and
- applying a voxelwise intensity algorithm to said smoothed registration and thereby produce a synthetic CT image volume having characteristics correlated to those of said first clinical image volume.
Dependencies are inferred from the claim text.