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US 2011/0230657 A1Published application
Process for preparing quetiapine fumarate-toluene-water
AssigneeAlembic Limited
InventorsRavi Ponnaiah, Ashok Prasad, Dineshkumar Ramabhai Panchasara, Mitul Bipinchandra Patwa, Ketan Bharatendubhai Patel
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Abstract
The present invention relates to an improved process for preparing Quetiapine fumarate of formula (I).
Claims6
A process for preparation of Quetiapine fumarate (I)
- comprising a step of reacting 11-chlorodibenzo [b,f][1,4]thiazepine (III)
- with 1-(2-hydroxyethoxy)ethylpiperazine (IV)
- in the presence of a solvent system comprising toluene and water to give Quetiapine (V);
A process for preparation of Quetiapine fumarate (I)
- comprising steps of:
- (i) dibenzo [b,f] [1,4]thiazepine-11(10-H)-one (II)
- with phosphorous oxychloride in the presence of N,N-dimethylaniline in toluene to give 11-chlorodibenzo [b,f][1,4]thiazepine (III);
- (ii) reacting 11-chlorodibenzo [b,f][1,4]thiazepine (III) with 1-(2-hydroxyethoxy)ethylpiperazine (IV)
- in the presence of a solvent system comprising toluene and water to give Quetiapine (V);
- (iii) converting Quetiapine (V) to Quetiapine fumarate (I) by reacting it with fumaric acid in methanol.
3 more elements
A process for purification of Quetiapine fumarate (I) comprising steps of
- (a) heating impure Quetiapine fumarate (I) with methanol;
- (b) adding water dropwise till clear solution obtained;
- (c) optionally reducing the volume of solution and;
- (d) cooling the reaction mixture to obtain pure Quetiapine fumarate (I).
1 more element
Dependencies are inferred from the claim text.