Anti-protozoa compounds
OwnerFiona Henriquez, Craig Robertsinventors
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Abstract
Use of a compound in the control of growth of at least one organism of the order of Amoebida, wherein said compound is capable of modulating the histidine biosynthesis pathway, and/or the methionine biosynthesis pathway and/or a pathway branching from the histidine biosynthesis pathway and/or methionine biosynthesis pathway in said organism.
Claims34
Use of a compound capable of modulating the histidine biosynthesis pathway, and/or the methionine biosynthesis pathway and/or a pathway branching from the histidine biosynthesis pathway and/or methionine biosynthesis pathway in the control of growth of at least one organism of the order of Amoebida.
A composition for use in modulating the histidine biosynthesis pathway and/or a pathway branching from the histidine biosynthesis pathway in Amoebida and/or the methionine biosynthesis pathway and/or a pathway branching from the methionine biosynthesis pathway in Amoebida, wherein the composition comprises a first compound capable of modulating the activity and/or expression of
- i) at least one enzyme of the histidine biosynthesis pathway and/or the methionine biosynthesis pathway
- ii) at least one enzyme of a pathway branching from the histidine and/or methionine biosynthesis pathway, and at least a second compound wherein said second compound is capable of modulating a further biosynthesis pathway present in Amoebida.
A compound being capable of modulating, preferably inhibiting, the histidine biosynthesis pathway, and/or the methionine biosynthesis pathway, and/or a pathway branching from the histidine biosynthesis pathway and/or a pathway branching from the methionine biosynthesis pathway for the treatment of a disease caused and/or contributed to by at least one organism of the order of Amoebida.
A method of treating a subject suffering from or susceptible to a disease caused and/or contributed to by a Amoebida, said method comprising the step of;
- administering to a subject in need thereof
- (a) a therapeutically effective amount of a compound capable of modulating, preferably inhibiting, the histidine biosynthesis pathway, and/or
- (b) a therapeutically effective amount of a compound capable of modulating, preferably inhibiting, the methionine biosynthesis pathway, and/or
- (c) a therapeutically effective amount of a compound capable of modulating, preferably inhibiting, a pathway branching from the histidine or methionine biosynthesis pathway in the Amoebida.
A composition for cleaning contact lenses and/or storing contact lenses comprising a compound capable of modulating, preferably inhibiting, the histidine biosynthesis pathway and/or a pathway branching from the histidine biosynthesis pathway and an anti-bacterial agent and/or the methionine biosynthesis pathway and/or a pathway branching from the methionine biosynthesis pathway.
An in vitro method of detecting an Amoebida in a sample, said method comprising the steps of;
- a) providing a sample;
- and
- b) detecting the presence of
- i) a gene and/or protein of the histidine biosynthesis pathway,
- ii) a gene and/or protein of the methionine biosynthesis pathway,
- iii) a gene and/or protein of a pathway branching from the histidine biosynthesis pathway or
- iv) a gene and/or protein of a pathway branching from the methionine biosynthesis pathway, wherein said gene is a gene encoded by Amoebida and said protein is a protein encoded by Amoebida.
A method of identifying an agent being capable of modulating an enzyme or enzymes of the histidine and/or methionine biosynthesis pathways and/or an enzyme or enzymes of any pathway branching from the histidine or methionine biosynthesis pathways in the Amoebida, said method comprising the steps of;
- (a) contacting a test agent with a system capable of expressing one or more enzymes of the histidine and/or methionine biosynthesis pathways and/or pathways branching from the histidine and/or methionine biosynthesis pathways from an Amoebida species;
- and
- (b) detecting a modulation of expression and/or activity of said one or more enzymes of the histidine and/or methionine biosynthesis pathways and/or pathways branching from the histidine and/or methionine biosynthesis pathways, wherein detection of said modulation of expression and/or activity of said one or more enzymes in step (b) is indicative that the test agent is an agent which is capable of modulating an enzyme of the histidine and/or methionine biosynthesis pathways and/or an enzyme of any pathway branching from the histidine and/or methionine biosynthesis pathways in the Amoebida.
A composition comprising a compound capable of modulating, preferably inhibiting, the histidine and/or methionine biosynthesis pathways or a pathway branching from the histidine and/or methionine biosynthesis pathways, and a second antimicrobial compound wherein the antimicrobial compound is effective in reducing the growth of MRSA or Legionella.
Use of the composition comprising a compound capable of modulating, preferably inhibiting, the histidine and/or methionine biosynthesis pathways and/or a pathway branching from the histidine and/or methionine biosynthesis pathways, and a second antimicrobial compound wherein the antimicrobial compound is effective in reducing the growth of MRSA or Legionella for the treatment of MRSA or Legionella.
A contact lens or eye prosthesis comprising a compound capable of modulating, preferably inhibiting, at least one enzyme of the histidine and/or methionine biosynthesis pathways and/or of a pathway branching from the histidine and/or methionine biosynthesis pathways in the Amoebida.
Dependencies are inferred from the claim text.