Detection of specific nitrated markers
AssigneeUniversite De Liege
InventorsJean-Yves Reginster, Michelle Deberg, Yves Henrotin, Stephan Christgau
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Abstract
Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to oxidative NO-modifications, utilizing an immunoassay comprising antibodies directed against nitrated and non-nitrated epitopes characteristic of a specific protein.
Claims12
1-26. (canceled)
A kit for performing an immunoassay comprising the steps of:
- detecting binding of an immunological binding partner which is immunoreactive with one or more aromatic amino acid residues in nitrated form of an amino acid sequence which is characteristic of a specific protein;
- the kid comprising:
- an immunological binding partner which is specifically reactive with the nitrated form of an aromatic amino acid residue in the context of an amino acid sequence which is characteristic of a specific protein;
- and means for detecting binding of said binding partner and said protein or a fragment thereof.
An immunological binding partner specifically reactive with the nitrated form of an aromatic amino acid residue in the context of an amino acid sequence which is characteristic of a specific protein.
Dependencies are inferred from the claim text.