Methods of diagnosing inflammatory bowel disease
AssigneePrometheus Laboratories Inc.
InventorsAugusto Lois, Bruce Neri
Life of this patent
Estimating the term…
Abstract
The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with inflammatory bowel disease (IBD) or a clinical subtype thereof. In particular, the present invention is useful for classifying a sample from an individual as an IBD sample using a statistical algorithm and/or empirical data. The present invention is also useful for differentiating between a clinical subtype of IBD such as Crohn's disease (CD) and ulcerative colitis (UC) using a statistical algorithm and/or empirical data. Thus, the present invention provides an accurate diagnostic prediction of IBD or a clinical subtype thereof and prognostic information useful for guiding treatment decisions.
Claims24
A method for classifying whether a sample from an individual is associated with inflammatory bowel disease (IBD), said method comprising:
- (a) determining the presence or level of at least one marker selected from the group consisting of an anti-neutrophil antibody, anti-Saccharomyces cerevisiae antibody, antimicrobial antibody, C-reactive protein (CRP), and combinations thereof in said sample;
- and
- (b) classifying said sample as an IBD sample or non-IBD sample using a statistical algorithm based upon the presence or level of said at least one marker.
(canceled)
19-77. (canceled)
A computer-readable medium including code for controlling one or more processors to classify whether a sample from an individual is associated with IBD, said code including instructions to apply a statistical process to a data set indicating the presence or level of at least one marker selected from the group consisting of an anti-neutrophil antibody, anti-Saccharomyces cerevisiae antibody, antimicrobial antibody, C-reactive protein (CRP), and combinations thereof in said sample to produce a statistically derived decision classifying said sample as an IBD sample or non-IBD sample based upon the presence or level of said at least one marker.
79-85. (canceled)
A system for classifying whether a sample from an individual is associated with IBD, said system comprising:
- (a) a data acquisition module configured to produce a data set indicating the presence or level of at least one marker selected from the group consisting of an anti-neutrophil antibody, anti-Saccharomyces cerevisiae antibody, antimicrobial antibody, C-reactive protein (CRP), and combinations thereof in said sample;
- (b) a data processing module configured to process the data set by applying a statistical process to the data set to produce a statistically derived decision classifying said sample as an IBD sample or non-IBD sample based upon the presence or level of said at least one marker;
- and
- (c) a display module configured to display the statistically derived decision.
87-93. (canceled)
Dependencies are inferred from the claim text.