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US 2011/0218361 A1Published application
Method for producing compound for preparation of anti-parkinson's disease drug
AssigneeEverlight USA, Inc.
InventorsChi-Hsiang Yao, Tsung-Ting Chen
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Abstract
The present invention provides a method for producing a compound of formula (I), which is used for preparing anti-Parkinson's disease drugs, rasagiline and rasagiline mesylate.
Claims10
A method for producing a compound of formula (I), comprising the steps of:
- performing a reaction of 1-indanone and propargylamine to form an imine intermediate of formula (II);
- and
- performing a reducing reaction of the imine intermediate of formula (II) and aluminum hydride in an aprotic solvent at a temperature in a range from −30 to −70° C. to obtain the compound of formula (I).
The method of claim 7, wherein the chiral acid is one of tartaric acid, malic acid and mandelic acid.
Dependencies are inferred from the claim text.