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US 2011/0218347 A1Published application
Process for the preparation of tetranorlabdane derivatives
AssigneeFirmenich SA
InventorCharles Fehr
Life of this patent
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Abstract
The present invention concerns a process for the preparation of a compound of formula (I) wherein the dotted line is a single bond and n is 1 or the dotted line is a double bond and n is 0, and wherein the relative configuration is as shown, in the form of any one of its diastereoisomers or enantiomers or mixtures thereof.
Claims13
-8. (canceled)
A process for the preparation of a furan of formula (I), or (I′)
- in the form of a racemic or optically active diastereoisomer, wherein the substituents in the positions 9a, 9b and 3a are in a relative configuration cis, and the hydrogen atom in position 5a and the oxygen atoms are in configuration trans relative to the methyl in position 9a;
- which comprises cyclizing an alcohol of formula (II), or respectively (II′)
- wherein the dotted lines indicate the presence of one carbon-carbon double bond in one of the indicated positions, said compounds (II) or (II′) being in a racemic or optically active form and, in the case of compound (II), being also in the form of diastereoisomer wherein the methyl in position 9a and the hydrogen atom in position 5a are in the relative trans configuration;
- while promoting the cyclizing with at least one Lewis acid and optionally an additive to assist in increasing selectivity or yield of the cyclizing.
1 more element
A compound of formula
- in the form of any one of its stereoisomers or mixtures thereof.
Dependencies are inferred from the claim text.