Crystalline polymorph of biopterin and production method thereof
AssigneeKaneka Corporation
InventorsHideo Kawachi, Yasuyoshi Ueda
Life of this patent
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Abstract
Crystalline solids A to E of biopterin are distinguished from each other by diffraction angle in an X-ray powder diffraction pattern measured using Cu—Kα radiation. The crystalline solid A is characterized by strong peak at 4.6° and peaks at 13.6°, 18.1° and 27.5°; the crystalline solid B is characterized by strong peak at 4.85° and peaks at 2.4°, 13.2°, 18.1° and 27.3°; the crystalline solid C is characterized by strong peak at 5.35° and peaks at 10.8°, 21.9° and 27.3°; the crystalline solid D is characterized by strong peak at 5.1° and peaks at 2.6°, 9.2°, 13.4°, 15.4°, 18.3°, 21.8° and 27.3°; and the crystalline solid E is characterized by strong peaks at 4.5° and 5.8°, and peaks at 10.6°, 15.6°, 20.0°, 20.7°, 23.8° and 27.3°.
Claims25
A crystalline solid A of biopterin, wherein the crystalline solid exhibits an X-ray powder diffraction pattern having strong peak at 4.6° and peaks at 13.6°, 18.1° and 27.5° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A method for producing a crystalline solid A of biopterin, comprising a step of adding an acid aqueous solution to an alkaline aqueous solution containing biopterin and a hydrophilic organic solvent, to precipitate the crystalline solid A of biopterin characterized by an X-ray powder diffraction pattern having strong peak at 4.6° and peaks at 13.6°, 18.1° and 27.5° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A crystalline solid B of biopterin, wherein the crystalline solid exhibits an X-ray powder diffraction pattern having strong peak at 4.85° and peaks at 2.4°, 13.2°, 18.1° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A method for producing a crystalline solid B of biopterin, comprising a step of adding an acid aqueous solution dropwise to an alkaline aqueous solution containing biopterin with stirring, to precipitate the crystalline solid B of biopterin characterized by an X-ray powder diffraction pattern having strong peak at 4.85° and peaks at 2.4°, 13.2°, 18.1° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A method for producing a crystalline solid B of biopterin, comprising a step of suspending biopterin in an aqueous solution of isopropanol, to produce the crystalline solid B of biopterin characterized by an X-ray powder diffraction pattern having strong peak at 4.85° and peaks at 2.4°, 13.2°, 18.1° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A crystalline solid C of biopterin, wherein the crystalline solid exhibits an X-ray powder diffraction pattern having strong peak at 5.35° and peaks at 10.8°, 21.9° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A method for producing a crystalline solid C of biopterin, comprising a step of suspending biopterin in at least one selected from methanol, ethanol and isopropanol, or suspending biopterin in an aqueous solution of methanol, an aqueous solution of ethanol or an mixed aqueous solution of methanol and ethanol, to precipitate the crystalline solid C of biopterin characterized by an X-ray powder diffraction pattern having strong peak at 5.35° and peaks at 10.8°, 21.9° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A crystalline solid D of biopterin, wherein the crystalline solid exhibits an X-ray powder diffraction pattern having strong peak at 5.1° and peaks at 2.6°, 9.2°, 13.4°, 15.4°, 18.3°, 21.8° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A method for producing a crystalline solid D of biopterin, comprising a step of adding an alkaline aqueous solution dropwise to a stirred acid aqueous solution containing biopterin, to precipitate the crystalline solid D of biopterin characterized by an X-ray powder diffraction pattern having strong peak at 5.1° and peaks at 2.6°, 9.2°, 13.4°, 15.4°, 18.3°, 21.8° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A crystalline solid E of biopterin, wherein the crystalline solid exhibits an X-ray powder diffraction pattern having strong peaks at 4.5° and 5.8°, and peaks at 10.6°, 15.6°, 20.0°, 20.7°, 23.8° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
A method for producing a crystalline solid E of biopterin, comprising a step of suspending biopterin in hexane, wherein the crystalline solid E exhibits an X-ray powder diffraction pattern having strong peaks at 4.5° and 5.8°, and peaks at 10.6°, 15.6°, 20.0°, 20.7°, 23.8° and 27.3° in degrees 2θ±0.1, measured using Cu—Kα radiation.
Dependencies are inferred from the claim text.