PHOSPHOROTHIOATE OLIGONUCLEOTIDES AND NON-NUCLEOSIDIC PHOSPHOROTHIOATES AS DELIVERY AGENTS FOR iRNA AGENTS
AssigneeAlnylam Pharmaceuticals, Inc.
InventorsMartin Maier, Muthiah Manoharan, Kallanthottathil G. Rajeev, Kevin Fitzgerald, Antonin de Fougerolles, Tatiane Novobrantseva, Anna Borodovsky, Maria Frank-Kamenetsky
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Abstract
The invention relates to use of single-stranded phosphorothioate oligonucleotides or non-nucleosidic phosphrothiaote as vehicles or carriers to modulate the biodistribution of iRNA agents.
Claims22
An iRNA agent that comprises at least one carrier oligomer, wherein said carrier oligomer is selected from the group consisting of a single-stranded phosphorothioate oligonucleotide, a non-nucleosidic phosphorothioate oligomer, a poly(G) oligonucleotide, a poly(I) oligonucleotide, and an oligonucleotide that can form a quadruplex structure.
Dependencies are inferred from the claim text.