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US 2011/0218333 A1Published application
Internalizing ErbB2 antibodies
AssigneeThe Regents of the University of California
InventorsJames D. Marks, Marie Alix Poul
Life of this patent
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Abstract
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.
Claims10
1-44. (canceled)
A nucleic acid encoding an antibody that specifically binds to the epitope bound by antibody F5 as encoded by ATCC plasmid deposit designation PTA7843) or antibody C1 (SEQ ID NO:
- 2)
53-54. (canceled)
Dependencies are inferred from the claim text.