Anti-il-6 antibodies, compositions, methods and uses
OwnerJill Giles-Komar, David Knight +2inventors
InventorsJill Giles-Komar, David Knight, David Peritt, Mohit Trikha
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Abstract
The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.
Claims9
(canceled)
(canceled)
An isolated antibody or antibody fragment that binds to human IL-6 comprising a heavy chain variable domain and a light chain variable domain containing complementarity determining regions (CDRs), and a constant region derived from one or more human antibodies, wherein the heavy chain variable domain comprises the CDR3 of SEQ ID No. 3.
5-21. (canceled)
23-39. (canceled)
An isolated IL-6 antibody or fragment thereof, comprising a murine variable and human constant region, wherein said antibody or specified portion or variant specifically binds at least one epitope comprising amino acids Gln29-Lev34 of human IL-6.
Dependencies are inferred from the claim text.