Inhibitor of Endogenous Human Interferon-Gamma
OwnerIvan Ivanov, Rumen Tsaney +3inventors
InventorsIvan Ivanov, Rumen Tsaney, Genoveva Nacheva, Hans-Guenther Grigoleit, Rolf Gunther
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Abstract
Inactivated protein derivatives of the hIFN-γ that preserve affinity to the hIFN-γ receptor are useful in the treatment of autoimmune diseases, especially multiple sclerosis.
Claims4
1-7. (canceled)
An inhibitor of endogenous human interferon-γ (hIFN-γ) comprising an inactivated recombinant hIFN-γ protein having binding affinity for the hIFN-γ receptor and consisting of recombinant protein hIFN-γ inactivated by UV radiation.
An inhibitor of endogenous human interferon-γ (hIFN-γ) consisting of recombinant hIFN-γ protein, inactivated by UV radiation, with preserved binding affinity for the hIFN-γ receptor.
An inhibitor of endogenous human interferon-γ (hIFN-γ) consisting of inactivated recombinant hIFN-γ protein having preserved binding affinity for the hIFN-γ receptor, wherein inactivation is effected by UV radiation.
Dependencies are inferred from the claim text.