Compound and composition and their uses thereof
AssigneeKrishani Biosciences (P) Ltd
InventorMAHESH KANDULA
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Abstract
A compound, composition, method of synthesizing and using the compound of formula 1 are disclosed. The compound of formula I also comprises of salts, polymorphs, solvates, and hydrates thereof. The compound may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for peroral, topical, transmucosal, inhalation, targeted delivery and sustained release formulations. Such compositions may be used to treat hepatic and genetic disorders related to copper overload.
Claims19
A compound, comprising;
- a pharmaceutically acceptable compound of formula 1:
- wherein R1, R2, and R3 each independently represents hydrogen, thiol, alkyl, alkyl thiol, acetyl thiol, disulfide, acyl, acylalkyl, alkenyl, alkylthioalkyl, alkynyl, alkoxyaryl, alkoxyalkyl, aryl, aralkyl, aryloxyalkyl, arylthioalkyl, cycloalkyl, ether, ester, heteroaryl, heterocyclyl, lower alkyl, sulfone, sulfoxide, or hydroxyalkyl;
- and
- wherein R4 represents at least one of a residue of guanidine, a residue of hydrazine, an acid, a residue of pyruvic acid, a residue of oxaloacetic acid, a residue of tocopherol, a residue of ascorbic acid, a residue of thiamine, thioctic acid, a residue of thioctic acid, a residue of acetyl cysteine, a residue of alpha-keto glutaric acid, a residue of dimercaprol, a residue of an NO donor, a residue of glutathione and an analog of any one of the foregoing.
A method of synthesis for a compound of formula 1, comprising:
- mixing (2S)-2-amino-3-methyl-3-sulfanyl-butanoic acid and dimercaprol in a pressure bottle;
- cooling the pressure bottle in dry ice and i-PrOH;
- adding isobutylene and sulfuric acid for two hours;
- stirring a resultant mixture for sixteen hours;
- and
- degassing the resultant mixture in the pressure bottle at atmospheric pressure.
A kit comprising a composition, comprising:
- a) at least one of R-(+)-lipoic acid, acetylcysteine and dimercaprol;
- b) at least one of zinc acetate and triethylene tetramine;
- and
- c) a compound of Formula 1:
- wherein R1, R2, and R3 each independently represents hydrogen, thiol, alkyl, alkyl thiol, acetyl thiol, disulfide, acyl, acylalkyl, alkenyl, alkylthioalkyl, alkynyl, alkoxyaryl, alkoxyalkyl, aryl, aralkyl, aryloxyalkyl, arylthioalkyl, cycloalkyl, ether, ester, heteroaryl, heterocyclyl, lower alkyl, sulfone, sulfoxide, or hydroxyalkyl;
- and
- wherein R4 represents at least one of a residue of guanidine, a residue of hydrazine, an acid, a residue of pyruvic acid, a residue of oxaloacetic acid, a residue of tocopherol, a residue of ascorbic acid, a residue of thiamine, thioctic acid, a residue of thioctic acid, a residue of acetyl cysteine, a residue of alpha-keto glutaric acid, a residue of dimercaprol, a residue of an NO donor, a residue of glutathione and an analog of any one of the foregoing.
Dependencies are inferred from the claim text.