Combination of Immuno Gene Therapy and Chemotherapy for Treatment of Cancer and Hyperproliferative Diseases
AssigneeEgen, Inc.
InventorsJason G. Fewell, Majed Matar, Jennifer Rice, Danny H. Lewis, Khursheed Anwer
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Abstract
Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
Claims19
A pharmaceutical composition comprising (1) a DNA plasmid that encodes an anti-proliferative molecule and (2) a lipopolymer, wherein the lipopolymer comprises a polyethylenimine backbone, wherein cholesterol and polyethylene glycol are each covalently linked to the polyethylenimine backbone.
A pharmaceutical composition comprising (1) an anti-proliferative siRNA, anti-proliferative sense RNA or anti-proliferative antisense RNA, and (2) a lipopolymer, wherein the lipopolymer comprises a polyethylenimine backbone, wherein cholesterol and polyethylene glycol are each covalently linked to the polyethylenimine backbone.
Dependencies are inferred from the claim text.