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US 2011/0218212 A1Published application
Predictive markers for egfr inhibitors treatment
OwnerPaul Delmar, Barbara Klughammer +2inventors
InventorsPaul Delmar, Barbara Klughammer, Verna Lutz, Patricia McLoughlin
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Abstract
The present invention provides biomarkers that are predictive for the response to treatment with an EGFR inhibitor in cancer patients. The markers are the genes GBAS, APOH, SCYL3, PMS2CL, PRODH, SERF1A, URG4A and LRRC31.
Claims12
An in vitro method of predicting the response of a cancer patient to treatment with an epidermal growth factor receptor (EGFR) inhibitor comprising:
- Determining the expression level of at least one gene selected from the group consisting of glioblastoma amplified sequence (GBAS), apolipoprotein H (APOH), SCY1-like 3 (SCYL3), PMS2CL, PRODH, SERF1A, URG4A and LRRC31 in a tumour sample of a cancer patient and comparing the expression level of the at least one gene in the tumour sample to a value representative of an expression level of the at least one gene in a non responding patient population, wherein a higher expression level of the at least one gene in the tumour sample of the patient is indicative for a patient who will respond to the treatment.
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Dependencies are inferred from the claim text.