Azaindole inhibitors of iap

A compound of formula (I)

• wherein
• X1 and X2 are each independently O or S;
• Y is a bond, (CR7R7)m, O or S;
• Z1, Z2, Z3 and Z4 are each independently N or CQ;
• Q is H, halogen, hydroxyl, carboxyl, amino, nitro, cyano, alkyl, a carbocycle or a heterocycle;
• wherein said alkyl, carbocycle and heterocycle is optionally substituted with one or more hydroxyl, alkoxy, acyl, halogen, mercapto, oxo, carboxyl, acyl, optionally substituted alkyl, amino, cyano, nitro, amidino, guanidino an optionally substituted carbocycle or an optionally substituted heterocycle;
• and wherein one or more CH2 or CH groups of an alkyl is optionally replaced with —O—, —S—, —S(O)—, S(O)2, —N(R8)—, —C(O)—, —C(O)—NR8—, —NR8—C(O)—, —SO2—NR8—, —NR8—SO2—, —NR8—C(O)—NR8—, —NR8—C(NH)—NR8—, —NR8—C(NH)—, —C(O)—O— or —O—C(O)—;
• R1 is H, OH or alkyl;
• or R1 and R2 together form a 5-8 member heterocycle;
• R2 is alkyl, a carbocycle, carbocyclylalkyl, a heterocycle or heterocyclylalkyl each optionally substituted with halogen, hydroxyl, oxo, thione, mercapto, carboxyl, alkyl, haloalkyl, acyl, alkoxy, alkylthio, sulfonyl, amino and nitro, wherein said alkyl, acyl, alkoxy, alkylthio and sulfonyl are optionally substituted with hydroxy, mercapto, halogen, amino, alkoxy, hydroxyalkoxy and alkoxyalkoxy;
• R3 is H or alkyl optionally substituted with halogen or hydroxyl;
• or R3 and R4 together form a 3-6 heterocycle;
• R3′ is H, or R3 and R3′ together form a 3-6 carbocycle;
• R4 and R4′ are independently H, hydroxyl, amino, alkyl, carbocycle, carbocycloalkyl, carbocycloalkyloxy, carbocycloalkyloxycarbonyl, heterocycle, heterocycloalkyl, heterocycloalkyloxy or heterocycloalkyloxycarbonyl;
• wherein each alkyl, carbocycloalkyl, carbocycloalkyloxy, carbocycloalkyloxycarbonyl, heterocycle, heterocycloalkyl, heterocycloalkyloxy and heterocycloalkyloxycarbonyl is optionally substituted with halogen, hydroxyl, mercapto, carboxyl, alkyl, alkoxy, amino, imino and nitro;
• or R4 and R4′ together form a heterocycle;
• R5 is H or alkyl;
• R6, and R6′ are each independently H, alkyl, aryl or aralkyl;
• R7 is H, cyano, hydroxyl, mercapto, halogen, nitro, carboxyl, amidino, guanidino, alkyl, a carbocycle, a heterocycle or —U-V;
• wherein U is —O—, —S—, —S(O)—, S(O)2, —N(R8)—, —C(O)—, —C(O)—NR8—, —NR8—C(O)—, —SO2—NR8—, —NR8—SO2—, —NR8—C(O)—NR8—, —NR8—C(NH)—NR8—, —NR8—C(NH)—, —C(O)—O— or —O—C(O)— and V is alkyl, a carbocycle or a heterocycle;
• and wherein one or more CH2 or CH groups of an alkyl is optionally replaced with —O—, —S—, —S(O)—, S(O)2, —N(R8)—, —C(O)—, —C(O)—NR8—, —NR8—C(O)—, —SO2—NR8—, —NR8—SO2—, —NR8—C(O)—NR8—, —C(O)—O— or —O—C(O)—;
• and an alkyl, carbocycle and heterocycle is optionally substituted with hydroxyl, alkoxy, acyl, halogen, mercapto, oxo, carboxyl, acyl, halo-substituted alkyl, amino, cyano nitro, amidino, guanidino an optionally substituted carbocycle or an optionally substituted heterocycle;
• R8 is H, alkyl, a carbocycle or a heterocycle wherein one or more CH2 or CH groups of said alkyl is optionally replaced with —O—, —S—, —S(O)—, S(O)2, —N(R8), or —C(O)—;
• and said alkyl, carbocycle and heterocycle is optionally substituted with hydroxyl, alkoxy, acyl, halogen, mercapto, oxo (═O), carboxyl, acyl, halo-substituted alkyl, amino, cyano nitro, amidino, guanidino an optionally substituted carbocycle or an optionally substituted heterocycle;
• R9 is H, alkyl or acyl;
• and
• m is 0 to 4;
• provided that the compound is other than:
• 2-[(2R)-1-[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl]-2-pyrrolidinyl]-1H-indole.