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US 2011/0218210 A1Published application
Compounds for treating abnormal cellular proliferation
AssigneeTaiga Biotechnologies, Inc.
InventorsYosef Refaeli, Brian Curtis Turner
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Abstract
Provided herein are compounds, compositions and methods for treating disorders mediated by abnormal cellular proliferation and processes for identifying such compounds.
Claims11
1-93. (canceled)
A process for identifying a therapeutic agent that selectively inhibits the growth of, or induces apoptosis in, in a cancer stem cell by:
- a. identifying at least one candidate compound;
- b. contacting a plurality of normal conditionally immortalized hematopoietic stem cells with the candidate compound;
- c. contacting a plurality of leukemic cancer stem cells with the candidate compound;
- d. detecting or measuring the impact of the candidate compound on the viability of the plurality of normal conditionally immortalized hematopoietic stem cells and the plurality of leukemic cancer stem cells;
- and
- e. comparing the impact of the candidate compound on viability of the plurality of normal conditionally immortalized hematopoietic stem cells to the impact of the candidate compound on viability of the plurality of leukemic cancer stem cells.
3 more elements
Dependencies are inferred from the claim text.