Individual and combination of mdivi-1 and nutlin-3 for topical or intravitreal ophthalmic use
OwnerIan H Chaninventor
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Abstract
Disclosed are pharmaceutical compositions comprising mdivi-1 and nutlin-3, individually and in combination, for topical or intravitreal ophthalmic delivery and a method of treatment comprising administering said composition when indicated for glaucoma, optic neuropathies including Leber Hereditary Optic Neuropathy, arteritic or non-arteritic Ischemic Optic Neuropathy, and retinal artery and vein occlusions.
Claims3
A method of treating glaucoma, ischemic optic neuropathy or retinal artery or vein occlusion by topical or intravitreal administration of nutlin-3, including the active enantiomer nutlin-3a, to an eye of a person in need once to four times a day or as one time or weekly intravitreal injections as the sole active agent.
A method of treating glaucoma, ischemic optic neuropathy or retinal artery or vein occlusion by topical or intravitreal administration of mdivi-1 to an eye of a person in need once to four times a day or as one time or weekly intravitreal injections as the sole active agent.
A method of treating glaucoma, ischemic optic neuropathy or retinal artery or vein occlusion by topical administration of nutlin-3 (including the active enantiomer nutlin-3a) to an eye of a person in need thereof, said improvement comprising topically administering to said eye, in a single composition, nutlin-3 and mdivi-1 once to four times a day topically or as one time or weekly intravitreal injections;
- as the sole active agents;
- wherein said method is as effective as administration of nutlin-3 once to four times a day and mdivi-1 once to four times a day or as one time or weekly intravitreal injections to said eye, herein the two compounds are administered in separate compositions.
Dependencies are inferred from the claim text.