Novel pyrazolone-derivatives and their use as pde-4 inhibitors

A compound of formula 1

• wherein
• R1 represents a phenyl derivative of formulae (a), (b) or (c)
• wherein
• R2 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or predominantly substituted by fluorine,
• R3 is 1-2C-alkoxy, 3-5C-cycloalkoxy, 3-5C-cycloalkylmethoxy or 1-2C-alkoxy which is completely or predominantly substituted by fluorine,
• R4 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or predominantly substituted by fluorine;
• R5 is 1-2C-alkyl and
• R6 is hydrogen or 1-2C-alkyl,
• or R5 and R6 together and with inclusion of the two carbon atoms, to which they are bonded, form a spiro-linked 5- or 6-membered hydrocarbon ring,
• R7 is 1-2C-alkoxy or 1-2C-alkoxy which is completely or predominantly substituted by fluorine,
• R8 is 1-2C-alkyl and
• R9 is hydrogen or 1-2C-alkyl,
• or R8 and R9 together and with inclusion of the two carbon atoms, to which they are bonded, form a spiro-linked 5- or 6-membered hydrocarbon ring,
• R10 is 1-3C-alkyl and
• R11 is 1-3C-alkyl,
• or R10 and R11 together with the carbon atom, to which they are bonded, form a spiro-linked 3-, 4-, 5- or 6-membered hydrocarbon ring,
• A is C(O) or S(O)2,
• R12 is phenyl, naphthalenyl, pyridinyl, quinolinyl, isoquinolinyl, quinoxalinyl, 1,6-naphthyridinyl, 1,8-naphthyridinyl, indolyl, phenyl substituted by R13, R14, R15 and R16, pyridinyl substituted by R17 and R18, naphthalenyl substituted by R19 and R20, quinolinyl substituted by R21 or indolyl substituted by R22,
• wherein
• R13 is halogen, cyano, hydroxy, hydroxycarbonyl, 1-4C-alkyl, trifluoromethyl, 1-4C-alkoxy, 1-4C-alkoxy which is completely or predominantly substituted by fluorine, 3-7C-cycloalkyloxy, 3-7C-cycloalkylmethoxy, benzyloxy, 2,6-dichlorobenzyloxy, amino, mono- or di-1-4C-alkylamino, aminocarbonyl, mono- or di-1-4C-alkylaminocarbonyl, aminocarbonyl-1-4C-alkoxy, 1-4C-alkylcarbonylamino, 1-4C-alkylcarbonyloxy, 1-4C-alkoxycarbonyl or 1-4C-alkoxycarbonyl-1-4C-alkoxy,
• R14 is hydrogen, halogen, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxy which is completely or predominantly substituted by fluorine, 1-4C-alkoxycarbonyl, amino or mono- or di-1-4C-alkylamino,
• R15 is hydrogen, halogen or 1-4C-alkyl,
• R16 is hydrogen or 1-4C-alkyl,
• R17 is halogen, 1-4C-alkyl, trifluoromethyl, 1-4C-alkoxy, amino, mono- or di-1-4C-alkylamino, piperidinyl or morpholinyl,
• R18 is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy,
• R19 is halogen, hydroxy, 1-4C-alkyl, 1-4C-alkoxy, amino or mono- or di-1-4C-alkylamino,
• R20 is hydrogen, 1-4C-alkyl or 1-4C-alkoxy,
• R21 is 1-4C-alkyl,
• R22 is 1-4C-Alkyl,
• or a salt, a stereoisomer or a salt of a stereoisomer of the compound.