Pyridoneamide derivatives, their manufacture and use as pharmaceutical agents

A compound of formula I,

• wherein
• R1 is phenyl, which is unsubstituted or substituted one or several times, independently, by
• a) alkyl,
• b) —OH,
• c) —O-alkyl,
• d) —S-alkyl,
• e) —S(O)2-alkyl,
• f) halogen,
• g) —NRR′,
• h) —CH2—NRR′,
• i) trifluoromethyl,
• j) trifluoromethoxy,
• k) heterocyclyl which is unsubstituted or substituted once or twice by alkyl or acetyl,
• l) —CH2-heterocycl,
• m) —C(O)—NRR′,
• n) —C(O)—NH—CH2-phenyl-R″, or
• o) —C(O)—NH-phenyl-R″;
• R2 is hydrogen or (C1-C3)alkyl;
• R3 is —X—R4;
• R4 is a) (C1-C4)alkyl;
• b) (C3-C6)cycloalkyl;
• c) a 5 to 7 membered heterocycle, which is unsubstituted or substituted once or twice, independently, by alkyl;
• d) phenyl, wherein the phenyl is unsubstituted or substituted one to three times, independently, by halogen, alkyl, —O—CH3, —N(CH3)2, trifluoromethyl or trifluoromethoxy;
• or
• e) heteroaryl;
• X is (C1-C4)alkylene, —S(O)2—, or a single bond, wherein the (C1-C4)alkylene is unsubstituted or substituted once or twice, independently, by hydroxy, alkyl or halogen;
• and
• R R′, and R″ are independently selected from hydrogen and (C1-C3)alkyl;
• or a pharmaceutically acceptable salts thereof.