Compounds of estrogen-related receptor modulators and the uses thereof

Compounds having Formula lor their pharmaceutical acceptable salts or stereo isomers:

• wherein,
• A, B, D, and E are each independently selected as CH or N;
• n is selected as 0, 1, 2, 3, or 4;
• in the following, a is 0 or 1;
• b is 0 or 1;
• R1 is selected from:
• 1)H;
• 2) halide;
• 3)OH;
• 4) NO2;
• 5)CO2H;
• 6) (C═O)aObC1˜C8 alkyl;
• 7) (C═O)aOb aryl;
• 8) (C═O)aObC2˜C8 alkenyl;
• 9) (C═O)aObC2˜C8 alkynyl;
• 10) ObC1˜C8 fluoroalkyl;
• 11) (C═O)aNR6R5;
• 12) CN;
• 13) (C═O)aObC3˜C8 cycloalkyl;
• 14) (C═O)aOb heterocycle;
• 15) SO2NR6R7;
• 16) SO2C1˜C8 alkyl;
• 17) (C═O)aObC0˜C8-NR6R5;
• the alkyl, aryl, alkenyl, alkynyl, cycloalkyl or heterocycle groups mentioned above can be substituted by 0, 1 or more substituted groups independently selected from R4;
• R2 is selected from:
• 1) H;
• 2) C1˜C8 alkyl;
• 3) aryl;
• 4) C3˜C8 alkenyl;
• 5) C3˜C8 alkynyl;
• 6) C1˜C8 fluoroalkyl;
• 7) C1˜C6 aryl alkyl;
• 8) C3˜C6 cycloalkyl;
• 9) heterocycle;
• the alkyl, aryl, alkenyl, alkynyl, cycloalkyl or heterocycle groups mentioned above can be substituted by 0, 1 or more substituted group independently selected from R4;
• R3 is selected from:
• 1) (C═O)aObC1˜C8 alkyl;
• 2) (C═O)aOb aryl;
• 3) (C═O)aObC2˜C8 alkenyl;
• 4) (C═O)aObC2˜C8 alkynyl;
• 5) ObC1˜C8 fluoroalkyl;
• 6) (C═O)aNR6R5;
• 7) (C═O)aObC3˜C8 cycloalkyl;
• 8) (C═O)aOb heterocycle;
• the alkyl, aryl, alkenyl, alkynyl, cycloalkyl or heterocycle groups mentioned above can be substituted by 0, 1 or more substituted groups independently selected from R4;
• R4 is selected from:
• 1) H;
• 2) halide;
• 3) OH;
• 4) NO2;
• 5) CO2H;
• 6) (C═O)aObC1˜C8 alkyl;
• 7) (C═O)aOb aryl;
• 8) (C═O)aObC2˜C8 alkenyl;
• 9) (C═O)aObC2˜C8 alkynyl;
• 10) ObC1˜C8 fluoroalkyl;
• 11) (C═O)aNR6R5;
• 12) CN;
• 13) (C═O)aObC3˜C8 cycloalkyl;
• 14) (C═O)aOb heterocycle;
• 15) SO2NR6R7;
• 16) SO2C1˜C8 alkyl;
• the alkyl, aryl, alkenyl, alkynyl, cycloalkyl or heterocycle groups mentioned above can be substituted by no more than 3 substituted groups independently selected from R5, OH, (C1˜C6) alkoxy, halide, COOH, CN, O(C═O)C1˜C6 alkyl, or NR5R6groups;
• R5 and R6 are each independently selected from:
• 1) H;
• 2) (C═O)aObC1˜C8 alkyl;
• 3) (C═O)aOb aryl;
• 4) (C═O)aObC2˜C8 alkenyl;
• 5) (C═O)aObC2˜C8 alkynyl;
• 6) ObC1˜C8 fluoroalkyl;
• 7) (C═O)aObC3˜C8 cycloalkyl;
• 8) (C═O)aOb heterocycle;
• 9) (C═O)aObC0˜C8 -NR6R5;
• the alkyl, aryl, alkenyl, alkynyl, cycloalkyl or heterocycle groups mentioned above can be substituted by no more than 3 substituted groups independently selected from R6;
• or R6 and R5 form a 4˜7-atom ring, or a bicyclic ring in which each ring is formed by 4˜7-atoms;
• the ring or bicyclic ring contains 1, 2, or 3 hetero atoms selected from N, O and S atom;
• the ring or bicyclic ring can be substituted by one or more substituted groups independently selected from R5.