Therapeutic uses of ampa receptor modulators for treatment of motor dysfunction
AssigneeThe Regents of the University of California
InventorsWalter E. Babiec, Shane A. Saywell, Jack L. Feldman, Wiktor A. Janczewski
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Abstract
The application describes treatment of motoneuronal dysfunctions or disorders using AMPA receptor modulators. Examples of a motoneuronal dysfunction or disorder include obstructive sleep apnea, snoring, multiple sclerosis, spinal cord injury, e.g., crush, partial or complete transection, motor neuron diseases, motor weakness due to aging, stroke, tumor, hemorrhage, degenerative or wasting diseases, and spasticity. One example of an AMPA receptor modulator is a benzothiadiazide compound. Another example of an AMPA receptor modulator is an ampakine. Yet another example of an AMPA receptor modulator is aniracetam.
Claims24
1-35. (canceled)
A method of increasing genioglossus muscle tone in a subject having sleep-disordered breathing comprising administering to the subject an effective amount of an AMPA receptor modulator sufficient to increase genioglossus muscle activity.
39-41. (canceled)
45-47. (canceled)
A method of treating snoring in a subject having snoring comprising administering to the subject an effective amount of an AMPA receptor modulator sufficient to reduce or inhibit snoring.
A method of treating obstructive sleep apnea in a subject having obstructive sleep apnea comprising administering to the subject an effective amount of a benzothiadiazide sufficient to reduce or inhibit obstructive sleep apnea.
A method of treating obstructive sleep apnea in a subject comprising administering to the subject an effective amount of aniracetam sufficient to reduce or inhibit obstructive sleep apnea.
62-100. (canceled)
Dependencies are inferred from the claim text.