PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS

A pyrrolo[2,3-d]pyrimidin-2-yl derivative according to formula I

• wherein
• R1 is C6-10aryl optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy and C3-6cycloalkyloxy, said C1-6alkyl, C3-6 cycloalkyl, C1-6alkyloxy and C3-6cycloalkyloxy being optionally substituted with one or more halogens or
• R1 is C3-8cycloalkyl or
• R1 is —C1-3alkyl-Z, wherein Z is C3-8cycloalkyl, C6-12aryl or a 5-10 membered heteroaryl ring system comprising 1-2 heteroatoms independently selected from O, S and N, said C6-10aryl and 5-10 membered heteroaryl ring system being optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy and C3-6cycloalkyloxy, said C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy and C3-6cycloalkyloxy being optionally substituted with one or more halogens;
• R2 is —C2-7alkyl-NR5R6 or
• R2 is —C0-4alkyl-Y wherein Y is a 4-8 membered saturated or unsaturated heterocyclic ring system comprising one or two heteroatomic moieties independently selected from O, S and N(R7)p, said heterocyclic ring system being optionally substituted with halogen, hydroxy, C1-6alkyl or C1-6 alkyloxy or
• R2 is —C0-2alkylC3-6cycloalkyl substituted with —NR8R9 or —CH2NR8R9;
• R3 is C1-6alkyl, C6-10aryl or C6-10arylC1-3alkyl, said C6-10aryl and C6-10arylC1-3alkyl being optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, C1-6alkyl, C3-6cycloalkyl, C1-6alkyloxy, C3-6cycloalkyloxy, —NHCOR10, —NHS(O)qR11, —CONR12R13, —S(O)rR14R15, and —NHCONR16R17 said C1-6alkyl C3-6 cycloalkyl, C1-6alkyloxy and C3-6cycloalkyloxy being optionally substituted with one or more halogens;
• R4 is H, C1-6alkyl, CN or halogen;
• R5-R9 are independently chosen from H and C1-4alkyl;
• R10 and R11 are independently C1-4alkyl;
• R12 and R13 are independently chosen from H and C1-4alkyl;
• R14-R17 are independently C1-4alkyl;
• p is 0 or 1 and
• q and r are independently 1 or 2
• or a pharmaceutically acceptable salt or solvate thereof.