Chemical compounds 251

A compound of formula IA,

• or salts thereof, wherein, —
• --- is individually at each occurrence selected from a single and double bond;
• n is selected from 0, 1, or 2;
• m is selected from 0, 1, or 2;
• A is selected from N and CR7;
• X is selected from O, S, CHR10 and NR11;
• Y is selected from N, CH, and C;
• R5, R6, and R7 are each individually and independently from hydrogen, C1-6alkyl, halogen, cyano, nitro, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, C1-6alkoxy, C1-6alkylthio, C1-6alkylamino, (C1-6alkyl)2amino, carbocyclyl, aryl, and heterocyclyl, wherein R5, R6, and R7 are each optionally substituted with one or more, the same or different, R12;
• R8 and R9 are each individually and independently selected from hydrogen, amino, hydroxyl, mercapto, C1-6alkyl, C1-6alkylamino, carbocyclyl, aryl, and heterocyclyl wherein R8 and R9 are each optionally substituted with one or more, the same or different, R15;
• R10 is selected from hydrogen, C1-6alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, C1-6alkoxy, C1-6alkylthio, C1-6alkylamino, (C1-6alkyl)2amino, C1-6alkylsulfamoyl, arylsulfamoyl, carbocyclyl, aryl, and heterocyclyl, wherein R10 is optionally substituted with one or more, the same or different, R12;
• R11 is selected from hydrogen, formyl, C1-6alkyl, C1-6alkanoyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, arylsulfonyl, C1-6alkoxycarbonyl, carbocyclyl, aryl, and heterocyclyl, wherein R11 is optionally substituted with one or more, the same or different, R12;
• R12 is selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, and heterocyclyl, wherein R12 is optionally substituted with one or more, the same or different, R16;
• R15 is selected from C1-6alkyl, C1-6alkanoyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, arylsulfonyl, and C1-6alkoxycarbonyl wherein R15 is optionally substituted with one or more, the same or different, R12;
• R16 is selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, aminomethyl, aminoethyl, aminopropyl, aminobutyl, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, and N-methyl-N-ethylsulfamoyl;
• and
• provided that R5, R6, and R7 are not all hydrogen and
• provided the compound is not 5-((5-nitro-2-(1-piperidinyl)phenyl)methylene)-2,4-thiazolidinedione or 5-(2-(4-morpholinyl)-5-nitrophenyl)methylene)-2,4-thiazolidinedione.

A compound of formula IC,

• or salts thereof, wherein,
• n is selected from 0, 1, 2, 3, 4, 5, 6, 7 or 8;
• X is selected from O, S, CHR10 and NR11;
• Y is selected from O, S, and NR13;
• R5, R6, and R7 are each individually and independently from C1-6alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, C1-6alkoxy, C1-6alkylthio, C1-6alkylamino, C1-6dialkylamino, carbocyclyl, aryl, and heterocyclyl, wherein R5, R6, and R7 are each optionally substituted with one or more, the same or different, R12;
• R10 is selected from hydrogen, C1-6alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, C1-6alkoxy, C1-6alkylthio, C1-6alkylamino, (C1-6alkyl)2amino, C1-6alkylsulfamoyl, arylsulfamoyl, carbocyclyl, aryl, and heterocyclyl, wherein R10 is optionally substituted with one or more, the same or different, R12;
• R11, R13, and R14 are each individually and independently selected from hydrogen, C1-6alkyl, C1-6alkanoyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, arylsulfonyl, and C1-6alkoxycarbonyl wherein R11 is optionally substituted with one or more, the same or different, R12;
• or R11 and R14, taken together with the atoms to which they are attached form a five, six, or seven membered heterocyclic ring optionally substituted with one or more, the same or different, R12;
• R12 is selected from halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfinyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, and heterocyclyl.

A compound of formula IX,

• or salts thereof, wherein
• R5 is selected from hydrogen, C1-6alkoxy, carbamoyl, and halogenated C1-6alkyl;
• R6 is selected from hydrogen, halogen, C1-6alkoxy, and 2-(1-piperidyl)ethoxy;
• R7 is selected from hydrogen, halogen, and C1-6alkoxy;
• R17 is a heterocarbocylcyl, wherein R17 is optionally substituted with one or more, the same or different, R18;
• R18 is selected from halogen, formyl, amino, C1-6alkyl, C1-6alkylamino, (C1-6alkyl)2amino, carbocyclyl, aryl, heterocyclyl, wherein R18 is optionally substituted with one or more, the same or different, R19;
• R19 is selected from amino, C1-6alkyl, hydroxy, carbocyclyl, and heterocyclyl wherein R19 is optionally substituted with one or more, the same or different, R20;
• and
• R20 is selected from amino, C1-6alkyl, and halogen.