Mucoadherents compositions and their use
AssigneeIncrementha PD&I - Pesquisa, Desenvolvimento e Inovecao de Famacos e Medicamentos Ltda.
InventorsHaline Fernanda Santana Castanho, Lupércio Calefe
Life of this patent
Estimating the term…
Abstract
The present invention has as its objective to provide mucoadherent compositions with enhanced properties of bioadhesivity, consistency, stability and vaginal pH regulation. It can also be the carrier of an active principle for the treatment or prophylaxis of disturbances or diseases caused in mucosa, particularly in the vaginal tract, as well as their use.
Claims28
1-40. (canceled)
A mucoadherent composition, wherein said composition is essentially free of oily substances and comprises:
- (a) 0.25 to 1.5% of a bioadherent polymer;
- (b) 0.25 to 1.5% of a gelifying polymer;
- (c) 17 to 25% of pharmaceutically acceptable excipients;
- and
- (d) water;
- with the condition that the ratio of bioadherent polymer/gelifying polymer is 1:1.
A mucoadherent composition, wherein said composition is a carrier of an active principle for treatment or prophylaxis of vaginal disturbances or diseases, essentially free of oily substances and comprising:
- (a) a therapeutically effective quantity of an active principle selected from the group consisting of hormonal agents, antibacterial agents, antifungal agents, antiprotozoan agents, antiviral agents, spermicidal agents, local anesthetic agents, anti-inflammatory agents and anti-spasmodic agents;
- and
- (b) an aqueous formulation base comprising:
- (i) 0.25 to 1.5% of a bioadherent polymer;
- (ii) 0.25 to 1.5% of a gelifying polymer;
- (iii) 17 to 25% of pharmaceutically acceptable excipients;
- and
- (iv) 25% to 90% of water,
- with the condition that the bioadherent polymer/gelifying polymer ratio is 1:1.
Dependencies are inferred from the claim text.