15-thia steroid compounds and compositions
OwnerJames M. Frinckeinventor
Life of this patent
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Abstract
The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the invention include methyl-2,3,4-trihydroxy-1-O-(7,17-dioxoandrost-5-ene-3β-yl)-β-D-glucopyranosiduronate, 16α,3α-dihydroxy-5α-androstan-17-one or 3,7,16,17-tetrahydroxyandrost-5-ene, 3,7,16,17-tetrahydroxyandrost-4-ene, 3,7,16,17-tetrahydroxyandrost-1-ene or 3,7,16,17-tetrahydroxyandrostane that can be used in the treatment method.
Claims19
A compound having the structure
- wherein the dotted line is an optional double bond;
- R1, R2, and R4 independently are —OH, an ester or an ether;
- R3 is —OH, an ester, an ether or halogen;
- R5 is —CH3 or —CH2OH;
- R6 is —H or —CH3;
- and R7 is —S—.
A pharmaceutical formulation comprising one or more excipients and a compound having the structure
- wherein the dotted line is an optional double bond;
- R1, R2, and R4 independently are —OH, an ester or an ether;
- R3 is —OH, an ester, an ether or halogen;
- R5 is —CH3 or —CH2OH;
- R6 is —H or —CH3;
- and R7 is —S—.
The pharmaceutical formulation of claim 16 wherein R1, R2 and R4 are —OH or an ester and R5 and R6 are —CH3.
Dependencies are inferred from the claim text.