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US 2011/0217709 A1Published application
Detection of chromsomal region copy number changes to diagnose melanoma
AssigneeThe Regents of the University of California
InventorsBoris Bastian, Daniel Pinkel
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Abstract
This invention provides methods of detecting melanoma. The methods comprises detecting a gain or loss of certain chromosomal regions that undergo copy number changes in melanoma.
Claims10
A method of detecting a melanoma in a patient, the method comprising:
- contacting a nucleic acid in a biological sample from the patient with a probe that selectively hybridization to a chromosomal region selected from the group consisting of 1q21, 1q32, 1q42, 5p15, 6p24, 6p23, 6p22, 6p21, 7q36, 9p24, 10q21, a region of 10q23.3 from about 89,698,198 to about 93,052,778, 10q25, 12q15, and 21q21;
- and detecting a change in the copy number of the chromosomal region that is indicative of melanoma, thereby detecting the melanoma.
Dependencies are inferred from the claim text.