Back to results
US 2011/0217708 A1Published application
Methods and compositions for detecting colon cancers
AssigneeCase Western Reserve University
InventorSanford D. Markowitz
Life of this patent
Estimating the term…
Abstract
This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as colon neoplasia.
Claims30
A method for detecting a vimentin-associated proliferative disorder, comprising:
- a) obtaining a sample from a patient;
- and
- b) assaying said sample for the presence of methylation within a nucleotide sequence as set forth in SEQ ID NO:
- 2 or fragments thereof;
- wherein methylation of said nucleotide sequence is indicative of a vimentin-associated proliferative disorder.
2 more elements
A method for detecting a vimentin-associated proliferative disorder in a subject, comprising detecting vimentin protein or nucleic acid expression in a sample from the subject.
A method for monitoring over time a vimentin-associated proliferative disorder comprising:
- a) detecting the methylation status of a vimentin nucleotide sequence in a sample from the subject for a first time;
- and
- b) detecting the methylation status of the vimentin nucleotide sequence in a sample from the same subject at a later time;
- wherein absence of methylation in the vimentin nucleotide sequence taken at a later time and the presence of methylation in the vimentin nucleotide sequence taken at the first time is indicative of regression of the proliferative disorder;
- wherein presence of methylation in the vimentin nucleotide sequence taken at a later time and the absence of methylation in the vimentin nucleotide sequence taken at the first time is indicative of progression of the proliferative disorder.
2 more elements
Dependencies are inferred from the claim text.