US 2011/0217448 A1 · METHOD FOR PREPARATION OF A CONTROLLED RELEASE SYSTEM

Abstract

The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery. In accordance with the present invention, the tem controlled release ” encompasses all kinds of controlled release, including slow release, sustained and delayed release. Particularly, the present invention results in active ingredients, entrapped in or otherwise incorporated in or coupled to polymer carriers or polymeric devices, such as micelles, nanoparticles, microspheres and other types of polymer devices for controlled release; the active ingredients are covalently bonded to the polymer carriers or polymeric devices.

Claims14

Dependent claims

A method for the preparation of a controlled release system comprising a polymer matrix incorporating an active ingredient, comprising the steps of:

(i) mixing an active ingredient comprising a reactive moiety with an aqueous solution or dispersion comprising polymer chains comprising at least one reactive moiety capable of reacting with the reactive moiety of the active ingredient, the polymer chains further being capable of cross-linking intra- or intermolecularly;
and
(ii) subjecting this mixture to cross-linking forming a polymer matrix under such conditions that simultaneous with the formation of the polymer matrix, the active ingredient is entrapped in this polymer matrix.

Dependencies are inferred from the claim text.

Facts

Application

13/119,199Filed 17 Sep 2009

Priority

18 Sep 2008

Published

8 Sep 2011

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 31/573
Substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone: substituted in position 21, e.g. cortisone,…
A61K 9/1075
Emulsions ; Emulsion preconcentrates; Micelles: microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of…
A61K 9/5138
Organic macromolecular compounds; Dendrimers: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone,…
A61K 47/56
The non-active ingredient being a modifying agent: the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or…

Method for preparation of a controlled release system

Life of this patent

Method for preparation of a controlled release system

Life of this patent

Abstract

Claims14