Methods and Compositions for Treating Pain Comprising a Statin
AssigneeWarsaw Orthopedic, Inc.
InventorsWilliam McKay, John Zanella
Life of this patent
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Abstract
Methods and compositions are provided for reducing, treating or preventing pain and/or inflammation in a patient in need of such treatment, the methods and compositions comprising administering a therapeutically effective amount of a statin or pharmaceutically acceptable salt thereof to a target tissue site beneath the skin.
Claims22
A method of treating pain and/or inflammation from sciatica or spondylolisthesis in a patient in need of such treatment, the method comprising locally administering one or more drug depots comprising a therapeutically effective amount of a statin or pharmaceutically acceptable salt thereof at or near a target tissue site beneath the skin of the patient to treat sciatic or spondylolisthesis pain and/or inflammation, wherein the one or more drug depots release 0.1 mg/kg/day to about 3 mg/kg/day of the statin at or near the target tissue site.
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A method of reducing pain and/or inflammation from sciatica, or spondylolisthesis in a patient in need of such treatment, the method comprising locally administering one or more drug depots comprising a therapeutically effective amount of a statin or pharmaceutically acceptable salt thereof at or near a target tissue site beneath the skin of the patient, wherein the one or more drug depots release 0.3 mg/kg/day to about 3 mg/kg/day of the statin at or near the target tissue site.
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A method of treating pain and/or inflammation from sciatica or spondylolisthesis in a patient in need of such treatment, the method comprising locally administering one or more drug depots consisting of a biodegradable polymer and a therapeutically effective amount of a statin or pharmaceutically acceptable salt thereof at or near a target tissue site beneath the skin of the patient to treat pain and/or inflammation from sciatica or spondylolisthesis, wherein the one or more drug depots release 0.3 mg/kg/day to about 3 mg/kg/day of the statin at or near the target tissue site.
Dependencies are inferred from the claim text.