Pharmaceutical compositions
OwnerDoris Angus, David John Duncalf +3inventors
InventorsDoris Angus, David John Duncalf, Alison Jane Foster, Steven Paul Rannard, Dong Wang
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Abstract
The present invention provides a substantially solvent-free nano-dispersion of an active in a carrier, wherein the carrier comprises an enteric carrier soluble at intestinal pH, but insoluble at stomach pH, and wherein the enteric carrier comprises at least 50% by weight of the nano-dispersion; and processes for the preparation of a substantially solvent-free nano-dispersion of an active in a carrier.
Claims20
A substantially solvent-free nano-dispersion of an active in a carrier, said carrier comprising a water-soluble carrier and an enteric carrier that is soluble at intestinal pH, but insoluble at stomach pH, wherein the enteric carrier comprises at least 50% by weight of the nano-dispersion, the active comprises at least 10% by weight of the nano-dispersion and the average particle size of the active is less than 1 μm.
A process for the production of a composition comprising an active, which process comprises the steps of:
- (a) providing a mixture comprising:
- (i) said active,
- (ii) a water-soluble carrier, and
- (iii) an enteric carrier that is soluble at intestinal pH, but insoluble at stomach pH, and
- (iv) a solvent for each of the active, the water-soluble carrier and the enteric carrier, and
- (b) drying the mixture to remove the, or each, solvent and obtain a substantially solvent-free nano-dispersion of said active in said water-soluble and enteric carriers, wherein the enteric carrier comprises at least 50% by weight of the nano-dispersion, the active comprises at least 10% by weight of the nano-dispersion and the average particle size of the active is less than 1 μm.
Dependencies are inferred from the claim text.