Dendrimeric peptides, pharmaceutical compositions and methods of using the same
AssigneeNew York University School of Medicine
InventorsNeville Robert Kallenbach, Anne W. Young, Zhigang Liu, Chunhui Zhou
Life of this patent
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Abstract
Novel dendrimeric peptide compounds are disclosed that have a formula represented by the following formula I: The compounds demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention and treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present peptides are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.
Claims85
An antimicrobial peptide according to formula I:
- wherein
- each L1 is —(CH2)n-;
- n is 2, 3, 4 or 5;
- each L2 is W*R;
- wherein W*R is -5-fluoro-DL-Tryptophan-ARG-, or
- and wherein the C(1) of C(O) is attached to NH and N(2) of NH is attached to H;
- and Z is selected from substituted or unsubstituted amino, hydroxy, substituted or unsubstituted alkoxy, and substituted or unsubstituted aryloxy;
- or a pharmaceutically acceptable salt thereof.
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Dependencies are inferred from the claim text.