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US 2011/0217365 A1Published application
Compositions and Methods for Gene Silencing
AssigneesRutgers, The State University of New Jersey, Silagene, Inc.
InventorsSamuel Ian Gunderson, Rafal Goraczniak
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Abstract
Compositions and methods for modulating the expression of a protein of interest are provided.
Claims25
A method of treating cancer in a subject, said method comprising administering at least one composition comprising at least one U1 adaptor for inhibiting the expression of at least one oncogene and at least one pharmaceutically acceptable carrier,
- wherein said U1 adaptor is a nucleic acid molecule comprising an annealing domain operably linked to at least one effector domain, wherein said annealing domain hybridizes to the pre-mRNA of said oncogene, and wherein said effector domain hybridizes to the U1 snRNA of U1 snRNP.
Dependencies are inferred from the claim text.