Conjugated suramin amino compounds for medical conditions
OwnerSammy O. Opiyoinventor
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Abstract
A modification of pharmacokinetics of suramin by use of amino compounds in modification of lipophilicity and protein binding characteristics for tackling the physico-chemical properties of suramin that gives it poor distribution in the body; formulating the resulting product in a form that leads to targeting body fluids like the lymphatic system when administered in a specific way; and determining the route of administration that maximizes targeting with a view to reducing the dosage so as to limit toxicity, hence increase tolerance by patient.
Claims13
1-5. (canceled)
A method of managing medical conditions, comprising:
- administering, to a human, an effective dose of conjugates and derivatives of suramin.
A method of treatment, comprising:
- administering, to a human, an effective dose of one or more of lysine, arginine, and other amino compounds to prevent an administration of an effective dose of suramin from resulting in serum albumin binding in the human.
A method of treatment, comprising
- administering an effective dosage of a suramin product to a human;
- and
- using one or more of lysine, arginine, and other amino compounds to protect the effective dosage of the suramin product from causing serum albumin binding in the human;
- wherein the effective dosage of the suramin product is about 1.5 mg/kg body weight per day.
Dependencies are inferred from the claim text.