Substrate having a surface for inhibiting adhesion of a target cell thereon and a method of preparing the same
AssigneeAgency for Science, Technology and Research
InventorsIsabel Rodríguez Fernández, Li Buay Koh
Life of this patent
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Abstract
A substrate having a surface for inhibiting adhesion of a target cell thereon, the substrate comprising an array of generally longitudinal projections having a longitudinal axis that extends from the surface of said substrate and having an aspect ratio of at least 2.5, wherein adjacent projections of said array are configured on the substrate such that the projections at least partially inhibit adhesion of a target cell thereon.
Claims24
A substrate having a surface for inhibiting adhesion of a target cell thereon, the substrate comprising an array of generally longitudinal projections having a longitudinal axis that extends from the surface of said substrate and having an aspect ratio of at least 2.5, wherein adjacent projections of said array are configured on the substrate such that the projections at least partially inhibit adhesion of a target cell thereon.
The substrate as claimed in any one of the preceding claims, wherein the aspect ratio of said projections is at least 3.
The substrate as claimed in any one of the preceding claims, wherein the aspect ratio of said projections is in the range of 3 to 20.
The substrate as claimed in any one of the preceding claims, wherein at least one of the substrate and projections are comprised of a biocompatible polymer.
The substrate as claimed in any one of the preceding claims, wherein said target cell is selected from the group consisting of thrombocytes, macrophages, dendritic cells, lymphocytes, granulocytes and bacteria.
The substrate as claimed in any one of the preceding claims, wherein the projections are flexible.
The substrate as claimed in any one of the preceding claims, wherein the projections have heights in the range of from 300 nm to 8000 nm.
The substrate as claimed in any one of the preceding claims, wherein the projections have widths in the range of from 80 nm to 800 nm.
The substrate as claimed in any one of the preceding claims, wherein the longitudinal axis of the projections are disposed at a substantially normal angle relative to a planar surface of said substrate.
A implantation device for implantation into a patient's body, wherein the device comprises a surface that has an array of longitudinal projections extending from a surface of said device and wherein said projections have an aspect ratio of at least 2.5, wherein adjacent projections of said array are configured on the surface of the device such that the projections at least partially inhibit adhesion of a target cell thereon.
A method of preparing a surface of a substrate, the method comprising the step of forming an array of longitudinal projections that extend from the surface of said substrate and have an aspect ratio of at least 2.5, wherein adjacent projections of said array are at a configuration on the substrate to at least partially inhibit adhesion of a target cell thereon.
A method of inhibiting adhesion of a target cell on a device in contact with body fluids, the method comprising the steps of:
- providing a device comprising a substrate having an array of longitudinal projections extending from the surface of said substrate and having an aspect ratio of at least 2.5, wherein adjacent projections of said array are configured on the substrate such that the projections at least partially inhibit adhesion of a target cell thereon;
- and
- contacting the body fluids with the substrate.
Dependencies are inferred from the claim text.