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OwnerDoris Angus, Alison Jayne Foster +3inventors
InventorsDoris Angus, Alison Jayne Foster, David Duncalf, Steven Paul Rannard, Dong Wang
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A process for the production of a soluble composition comprising a water-insoluble active which comprises either the steps of: a) providing a liquid mixture comprising: i) a dissolved water-insoluble active, ii) a dissolved water-soluble carrier, iii) a solvent for each of the active and the carrier, and b) spray-granulating the mixture to remove the, or each, solvent and obtain a substantially solvent-free nano-dispersion of the water-insoluble active in the carrier said water-insoluble active being in nano-particles having a size range of 999-20 nm; or, the steps of: a) providing a substantially solvent-free powder comprising a water-insoluble active dispersed in a water soluble carrier, said water-insoluble active being in nano-particles having a size range of 999-20 nm, and, b) spray-granulating the powder to obtain larger and denser particles. The invention also relates to solvent-free, granular products with a particle size in the range 20 microns to 10 mm and a bulk-density of greater than 0.4 g/cm3 comprising a water-soluble carrier material, the carrier material having dispersed therein a water-insoluble active, wherein on addition of water the carrier dissolves to form an aqueous dispersion of the active with a peak (z-average) particle size of below 800 nm, preferably below 500 nm and more preferably below 200 nm. The invention also relates to an analogous “reverse” process in which the active is water soluble and the carrier is oil soluble.
A process for the production of a water-soluble composition comprising a water-insoluble active which comprises the steps of:
A process for the production of a water-soluble composition comprising a water-insoluble active which comprises the steps of:
A solvent-free, granular product with a particle size in the range of 20 microns to 10 mm and a bulk-density of greater than 0.4 g/cm3 comprising a water-soluble carrier material, the carrier material having dispersed therein a water-insoluble active, wherein on addition of water the carrier dissolves to form an aqueous dispersion of the active with a peak particle size of below 800 nm.
A process for the production of an oil-soluble composition comprising a water-soluble active which comprises the steps of:
A process for the production of an oil-soluble composition comprising a water-soluble active which comprises the steps of:
A process for preparing a composition comprising a water-soluble active and a water-insoluble carrier, which comprises the steps of:
A process for preparing a composition comprising an water-soluble active and an oil-soluble carrier which comprises the steps of:
A solvent-free, granular product with a particle size in the range of 20 microns to 10 mm and a bulk-density of greater than 0.4 g/cm3 comprising an oil-soluble carrier material, the carrier material having dispersed therein a water-soluble active, wherein on addition of oil the carrier dissolves to form an dispersion of the active with a peak particle size of below 800 nm.
Dependencies are inferred from the claim text.