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US 2011/0217338 A1Published application
HIV-1 Envelope Based Fragments
OwnerSanjay K. Phogat, Raghavan Varadarajan +1inventors
InventorsSanjay K. Phogat, Raghavan Varadarajan, Sanchari Bhattacharyya
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Abstract
The present application relates to a novel HIV-1 envelope fragments containing the B12 epitope which may be utilized as an HIV-1 vaccine immunogen, in particular for eliciting broad neutralizing antibodies following a prime-boost immunization. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.
Claims9
A gp120 construct comprising an amino acid sequence of:
- (a) b121a having the amino acid sequence DSSSQN GSAGSA SGGDPEIVTHWHNCGGEFHYCNSTQLKN GSAGS GSDTITLPCRIKQN NG KAPPISGQIRCSSNQ NG SVEENCTGAGHCNIARAKHNNT (SEQ ID NO:
- 1) or
- (b) b122a having the amino acid sequence GSDTITLPCRIKQN NG KAPPISGQIRCSSNN NG SVEENCTGAGHCNIARAKWNNT GSAGSAGSA SGGDPEIVTHDHNCGGEFKYCNSTQLKN (SEQ ID NO:
- 2) or
- (c) b122a-K104F or
- (d) b122a-30C-36C-K104F.
3 more elements
Dependencies are inferred from the claim text.