Chimpanzee Adenovirus Vaccine Carriers

An isolated recombinant chimpanzee adenovirus serotype comprising a nucleic acid sequence encoding a hexon protein, the nucleic acid sequence selected from the group consisting of:

• a SEQ ID NOS:
• 16-25, 41, 43, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, and 117.

An isolated recombinant chimpanzee adenovirus serotype comprising a nucleic acid sequence encoding a fiber protein, the nucleic acid sequence selected from the group consisting of:

• SEQ ID NOS:
• 6-15, 42, 44, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76 and 78.

A replication defective chimpanzee adenoviral (ChAd) vector comprising a nucleotide sequence derived from an adeonovirus selected from the group of isolates consisting of ECACC accession numbers 03121201 (ChAd4), 03121202 (ChAd5), 03121203 (ChAd7), 03121204 (ChAd9), 03121205 (ChAd10), 03121206 (ChAd11), 03121207 (ChAd16), 03121208 (ChAd17), 03121209 (ChAd19) and 03121210 (ChAd20) and a transgene which encodes at least one immunogen operatively linked to regulatory sequences which direct expression of said transgene in mammalian cells, wherein said vector is at least partially deleted in E1 and devoid of E1 activity.

(canceled)

(canceled)

-21. (canceled)

A method of eliciting an immune response in a mammal comprising administering to said mammal a sufficient amount of the ChAd vector of claim 46, wherein administration of the ChAd vector elicits a primary immune response.

-29. (canceled)

-34. (canceled)

-41. (canceled)

A recombinant chimpanzee adenoviral (ChAd) vector which is at least partially deleted in E1 and devoid of E1 activity, wherein the adenoviral vector is derived from a chimpanzee adenovirus serotype selected from the group consisting of:

• ChAd3, ChAd6, ChAd20, ChAd4, ChAd5, ChAd7, ChAd9, ChAd10, ChAd11, ChAd16, ChAd17, ChAd19, ChAd8, ChAd22, ChAd24, ChAd26, ChAd30, ChAd31, ChAd37, ChAd38, ChAd44, ChAd63 and ChAd82.