Inactivation of Reverse Transcriptases By Azido-diarylpyrimidines
AssigneeAdan Rios
InventorAdan Rios
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Abstract
Azido-diarylpyrimidine (azido-DAPY) compounds, and compositions containing such compounds, are provided. In addition, methods of using azido-diarylpyrimidines to inactivate reverse transcriptases, prepare inactivated viruses, and treat or prevent viral infections are also provided.
Claims25
A compound having the formula of formula (I):
- wherein R1, R2, and R3 are independently N3 or lower alkyl, with the proviso that at least one of R1, R2, and R3 is N3.
A composition comprising:
- a compound having the formula of formula (I):
- wherein R1, R2, and R3 are independently N3 or lower alkyl, with the proviso that at least one of R1, R2, and R3 is N3;
- and
- a pharmaceutically acceptable carrier.
A method of inactivating a reverse transcriptase comprising:
- contacting a reverse transcriptase with an azido-diarylpyrimidine;
- and
- irradiating the reverse transcriptase and the azido-diarylpyrimidine with ultraviolet light to inactivate the reverse transcriptase.
A composition comprising a retrovirus particle and an azido-diarylpyrimidine.
A method of inactivating a retrovirus comprising:
- contacting a retrovirus with an azido-diarylpyrimidine;
- and
- irradiating the retrovirus and the azido-diarylpyrimidine with ultraviolet light to inactivate the retrovirus.
A method of eliciting an immune response comprising administering a retroviral particle comprising a reverse transcriptase covalently bound to an azido-diarylpyrimidine to a subject, wherein an immune response is elicited in the subject.
Dependencies are inferred from the claim text.