Vaccine
OwnerCarine CAPIAU, Marguerite Deschamps +4inventors
InventorsCarine CAPIAU, Marguerite Deschamps, Pierre Michel Desmons, Craig Antonyjoseph Laferriere, Jan Poolman, Jean-Paul Prieels
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Abstract
The present invention relates to the field of bacterial polysaccharide antigen vaccines. In particular, the present invention relates to vaccines comprising a pneumococcal polysaccharide antigen, typically a pneumococcal polysaccharide conjugate antigen, formulated with a protein antigen form Streptococcus pneumoniae, and optionally a Th1-inducing adjuvant.
Claims10
-6. (canceled)
A polyvalent immunogenic composition comprising:
- at least seven Streptococcus pneumoniae polysaccharide antigens from at least seven different serotypes;
- and
- at least one Streptococcus pneumoniae protein antigen or immunologically functional equivalent thereof,
- wherein
- (i) a first Streptococcus pneumoniae polysaccharides is a serotype 18C polysaccharide conjugated to a carrier protein,
- (ii) a second Streptococcus pneumoniae polysaccharides is a serotype 19F polysaccharide conjugated to a carrier protein,
- v(iii) a third Streptococcus pneumoniae polysaccharides is a serotype 23F polysaccharide conjugated to a carrier protein,
- (iV) a fourth Streptococcus pneumoniae polysaccharides is a serotype 4 polysaccharide conjugated to a carrier protein,
- (v) a fifth Streptococcus pneumoniae polysaccharides is a serotype 6B polysaccharide conjugated to a carrier protein,
- (vi) a sixth Streptococcus pneumoniae polysaccharides is a serotype 9V polysaccharide conjugated to a carrier protein and
- wherein the at least one Streptococcus pneumoniae protein antigen or immunologically functional equivalent thereof is pneumolysin wherein the pneumolysin is prepared by chemically detoxifying the pneumolysin.
An immunogenic composition as claimed herein additionally comprising an adjuvant.
Dependencies are inferred from the claim text.