T cell epitopes of the cyn d 1 allergen from bermuda grass pollen
AssigneeCircassia Limited
InventorsRobyn O'HEHIR, Jennifer ROLLAND
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Abstract
The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having Bermuda grass allergy and genetic sequences encoding same. These molecules are preferentially immunointeractive with T cells in subjects having a Bermuda grass pollen allergy. The molecules of the present invention are useful in the development of diagnostic, therapeutic and prophylactic agents for conditions characterised by an aberrant, inappropriate or otherwise unwanted immune response to Bermuda grass pollen or derivative or homologue thereof.
Claims22
1-29. (canceled)
An isolated peptide which is of 5 to 30 amino acids in length, said peptide including at least one T cell epitope from an amino acid sequence selected from the group consisting of SEQ ID NO:
- 12, SEQ ID NO:
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- 20, SEQ ID NO:
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- 27, or from a modified variant of said amino acid sequence including at least one amino acid insertion, deletion or modification;
- or an isolated nucleic acid molecule comprising a sequence of nucleotides encoding or complementary to a sequence encoding said peptide;
- or a pharmaceutical composition comprising said peptide or said nucleic acid molecule together with one or more pharmaceutically acceptable carriers or diluents.
Dependencies are inferred from the claim text.